Alcohol, drug, and suicide-related death rates are rising in the U.S. and ultimately cost 186,763 American lives in 2020.This is a 20% one-year increase in the combined death rate. In Florida, the number of deaths per 100,000 from alcohol, drugs, and suicide combined was 60.4 in 2020 – a 21% rise from 2019. Stress, anxiety, grief, and financial hardship resulting from the COVID-19 pandemic may have contributed to these increases. Investing in evidence-based programs that promote health and prevent substance misuse and suicide is critical.